The Research Initiatives
Our precision medicine focus allows for unique models of research analysis not otherwise available in standard clinical trials. We also focus our efforts on novel clinical companion diagnostics, food conditioning programs, food dosing mechanisms, and more to assure maximal efficiency of treatment and minimal side effects. Our in-house basic science laboratory studies new mechanisms of molecular food allergy diagnostics at the level of DNA, blood, the gastrointestinal tract, and other important organ systems.
Clinical Precision Medicine Research
Precision medicine advances science and medical treatment in a complex yet effective approach of the “N=1”. The N of any study is the number of patients. With more than 2,500 patients treated for severe food allergic disease, the N of our institute exceeds that of many worldwide. The beauty of precision medicine is we are able to take thousands of individuals and utilize each of their cases to unmask millions of data points in their system of “1”. This unique approach is advocated by the NIH, FDA and leading research centers across the globe. While complex and difficult in its statistical analysis, this class of research offers the greatest hope in analyzing the “personalized” medicine behind food allergy treatment.
Translational Science Research
Translational research is classically referred to as “from bench to bedside”. Each of our patients undergoes 300 or more diagnostic biomarker tests. This data is reflective of their immune system from the bone marrow to the gastrointestinal tract. We utilize this data to extrapolate novel findings and study them in the clinical food allergy world. This approach aids in creating the best diagnostics possible in food allergy. Additionally, the long-term follow-up of patients involving the standardization of biomarkers will be critical to the lifelong treatment outcomes of food allergy patients.
SoCal Food Allergy is home to basic science research focused on food allergic disease. Research at the level of DNA, RNA, immune cells, and more are critical to the development of newer treatments for food allergy. We are particularly focused on the development of newer biomarkers which can predict and reflect short-term molecular changes and long-term impact changes toward immune system tolerance. Such markers are currently not available. With the advent of such markers, patients undergoing immunotherapy can receive appropriate changes to treatment regimens to maximize molecular and clinical outcomes.
Our Recent Peer-Reviewed Publications
Randhawa I. et al. Correlating RAST, Component Levels, Skin Testing, and Epinephrine Requirements in Patients with Anaphylaxis to Peanut. Annals of Allergy, Asthma and Immunology. Volume 117, Number 5, Supplement 1. P213. Nov 2016.
Randhawa I and Morphew T. Diagnostic Associations Of Ara h8 and Ara h9 Components In Peanut-allergic Children. Annals of Allergy, Asthma and Immunology. Volume 117, Number 5, Supplement 1. P168.
Randhawa I, et. Al. Correlation of Negative Tree Nut Skin-Prick Tests and Successful Tree Nut Food Challenges Among Peanut-Allergic Children. Journal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB399. May 2016.