How does TIP work?

The Process: Every SoCal Food Allergy patient is treated individually
Intake and Diagnostics

The first step in the Tolerance Induction Program is a 90-minute consultation with one of our qualified physicians.  This consultation includes a full patient history and examination including lab work and other testing, as needed.  Testing may include:

  • Third Generation Component Resolved Diagnostics (blood)
  • Skin prick testing
  • Specific IgE Blood testing (i.e. RAST)
  • Immune function analysis
  • Lung function analysis
  • GI testing
  • Patch testing
Review & Recommendations for Treatment (4 - 6 weeks)

Your second visit in the Tolerance Induction Program provides you with a comprehensive picture of your child’s food allergy profile, while laying the groundwork for the specific plan of action that will guide your child to true food freedom.

  • Allergy phenotype classification and food categorization (i.e. “allergic,” “sensitized,” or “tolerant”)
  • Diagnosis of any connected and underlying conditions (i.e. immune-deficiency, etc.)
  • Pre-TIP treatment of any underlying and connected conditions (i.e. environmental allergies, asthma, etc.)
  • Physician presents a patient-specific plan for TIP based on each patient’s unique immune system
Tolerance Induction (12 - 14 months on average)

The next phase of TIP is tolerance induction.   During this period — on average 12-14 months — your child will begin a very specific plan of incremental home dosing coupled with in-office challenge visits.

  • Most patients are safely treated at the SoCal Food Allergy Clinic, located across the street from Miller Children’s Hospital, where doses and challenges are administered by our licensed providers and vitals are monitored by our professional medical team.
  • Patients determined to be “higher risk” may be treated in the hospital with emergency facilities on site.
  • All patients have 24-hour on-call support.
  • Patients will first challenge any foods to which they are determined to be “tolerant” at an adult passing dose (i.e. 10-12 grams for most tree nuts).
  • Foods to which a patient is “sensitized” will then be dosed on a daily basis from home, with the first dose given in the Clinic.
  • After approximately 4-6 weeks of home dosing with 24/7 on-call support, the patient undergoes an in-office challenge.
  • Once patients achieve an adult passing dose, they are instructed to consume a regular “maintenance” dose comparable to regular U.S. dietary intake.
  • Foods to which a patient is “allergic” will be introduced in the Clinic under monitoring at an induction dose (established by results of comprehensive diagnostics). The patient then doses at home for approximately 6 weeks (this may vary, depending upon the allergen), including weekly up-doses, with 24/7 on-call support.  The patient then returns for an in-Clinic, large dose escalation or “challenge” and continues eating a daily “maintenance” dose until diagnostic values allow a reduction in dosing over time.
Long-Term Monitoring & Follow-Up Care
Larger maintenance doses taken less frequently (i.e. 30 grams of peanut eaten monthly) increase patients’ safety, improve their compliance and allow graduates to consume as much of their former allergen as they want without fear of reaction.  Once our patients achieve immunological dietary tolerance, we continue to monitor and follow them over the long term.
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How does TIP differ?

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