How does the Tolerance Induction Program work?

Each child’s food allergy treatment should be just as unique as they are.

The Tolerance Induction Program is built on over a decade of diagnostic data collected from the patients we have treated.  This amounts to over 180 million data points.  What is the purpose of collecting all that data?  The data allows us to use high-powered mathematics and analytics to best understand food allergy and how to safely treat each child to overcome their unique food allergies.  Each child’s data directly drives their treatment — down to the milligram of food protein for each dose throughout the program.  This means every child receives an entirely unique form of therapy.  It also means that each new case grows the amount of data that we can continually study and analyze – leading to an even better understanding of food allergy and an even more efficient treatment program.

Being a Part of Research Counts

Our patients and their families can feel good about being a part of a program that not only treats their food allergies, but also allows our research team to advance the food allergy treatment cause for all children. Our long-term treatment and research model actively and successfully treats patients in our clinic while our research team continuously studies blood and immune cells in our on-site laboratory to better understand how we can safely speed up the treatment process.

The Process:  Every SoCal Food Allergy Patient is treated individually.


Stage 1:  Intake and Diagnostics (1 Day)

  • 90-minute consultation with physician including full patient history and examination
  • Lab work and other testing as needed, such as:
    • Third Generation Component Resolved Diagnostics (blood)
    • Skin prick testing
    • Specific IgE Blood testing (i.e. RAST)
    • Immune function analysis
    • Lung function analysis
    • GI testing
    • Patch testing

Review and Recommendations for Treatment (4-6 Weeks)

  • Allergy phenotype classification and food categorization (i.e. “allergic,” “sensitized,” or “tolerant”)
  • Diagnosis of any connected and underlying conditions (i.e. immunedeficiency, etc.)
  • Pre-TIP treatment of any underlying and connected conditions (i.e. environmental allergies, asthma, etc.)
  • Physician presents a patient-specific plan for TIP based on each patient’s unique immune system

Tolerance Induction (Average 12-14 months)

  • Most patients are safely treated at the SoCal Food Allergy Clinic, located across the street from Miller Children’s Hospital, where doses and challenges are administered by a physician and vitals are monitored by our professional medical team.  Patients determined to be at “higher risk” may be treated in the hospital with emergency facilities on site. All patients have 24-hour on-call support.
  • Patients will first challenge any foods to which they are determined to be “tolerant” at an adult passing dose (i.e. 10-12 grams for most tree nuts).
  • Foods to which a patient is “sensitized” will then be dosed on a daily basis from home, with the first dose given in the Clinic. After approximately 4-6 weeks of home dosing with 24/7 on-call support, the patient undergoes an in-office challenge. Once patients achieve an adult passing dose, they are instructed to consume a regular “maintenance” dose comparable to regular U.S. dietary intake.
  • Foods to which a patient is “allergic” will be introduced in the Clinic under monitoring at an eliciting dose (established by results of comprehensive diagnostics). The patient then doses at home for approximately 6 weeks (sometimes longer for peanut), including weekly up-doses, with 24/7 on-call support. Patient returns for an in-Clinic large dose escalation or challenge and continues eating a daily “maintenance” dose until diagnostic values allow a reduction in dosing over time.

Long-Term Monitoring and Follow-Up Care

Larger maintenance doses taken less frequently (i.e. 30 grams of peanut eaten monthly) increase patients’ safety, improve their compliance, and allow graduates to consume as much of their former allergen as they want. Once our patients achieve immunological dietary tolerance, we continue to monitor and follow them over the long term.

From Fear and Isolation to Hope and Freedom

Meet just a few of the graduates of our Tolerance Induction Program who now experience true food freedom.

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