SoCal Food Allergy Research Initiatives: Focused on the spectrum of food allergy research.

Clinical Precision Medicine Research

Precision medicine advances science and medical treatment in a complex yet effective approach of the “N=1”. The N of any study is the number of patients. With more than 2,500 patients treated for severe food allergic disease, the N of our institute exceeds that of many worldwide. The beauty of precision medicine is we are able to take thousands of individuals and utilize each of their cases to unmask millions of data points in their system of “1”. This unique approach is advocated by the NIH, FDA and leading research centers across the globe. While complex and difficult in its statistical analysis, this class of research offers the greatest hope in analyzing the “personalized” medicine behind food allergy treatment.

Translational Science Research

Translational research is classically referred to as “from bench to bedside”. Each of our patients undergoes 300 or more diagnostic biomarker tests. This data is reflective of their immune system from the bone marrow to the gastrointestinal tract. We utilize this data to extrapolate novel findings and study them in the clinical food allergy world. This approach aids in creating the best diagnostics possible in food allergy. Additionally, the long-term follow-up of patients involving the standardization of biomarkers will be critical to the lifelong treatment outcomes of food allergy patients.

Laboratory Research

SoCal Food Allergy is home to basic science research focused on food allergic disease. Research at the level of DNA, RNA, immune cells, and more are critical to the development of newer treatments for food allergy. We are particularly focused on the development of newer biomarkers which can predict and reflect short-term molecular changes and long-term impact changes toward immune system tolerance. Such markers are currently not available. With the advent of such markers, patients undergoing immunotherapy can receive appropriate changes to treatment regimens to maximize molecular and clinical outcomes.
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Dr. Nathan Marsteller, PhD

Dr. Nathan Marsteller comes to the Southern California Food Allergy Institute from the University of Nebraska in Lincoln, where he completed both his Ph.D and post-doctorate at the renowned Food Allergy Research and Resource Program (FARRP). At UNL, Dr. Marsteller focused on developing animal models in both germ-free and conventional mice, molecular biology, immunology, and microbiology. His hands-on work was designed to advance allergenicity safety assessments of novel food proteins. Dr. Marsteller’s unique background and research expertise are ideally suited for SoCal Food Allergy’s innovative research model. Under his leadership, SoCal Food Allergy is studying the interactions of the immune system and genetic regulation as they relate to rare diseases – in particular, allergy and lung development. Dr. Marsteller aims to develop new diagnostic tools to define and understand novel immune biomarkers. As understanding of these biomarkers grows, SoCal Food Allergy is uniquely positioned to identify the underpinning mechanisms of food allergy – further advancing our mission to provide cutting-edge care and drive treatment discovery at a pace which helps our patients today.

Recent Peer-Reviewed Publications

Randhawa I and Morphew T.  Diagnostic Associations Of Ara h8 and Ara h9 Components In Peanut-allergic Children. Annals of Allergy, Asthma and Immunology.  Volume 117, Number 5, Supplement 1.  P168.  Nov 2016. http://epo.epostersonline.net/acaai2016/node/1088
Randhawa I. et al. Correlating RAST, Component Levels, Skin Testing, and Epinephrine Requirements in Patients with Anaphylaxis to Peanut. Annals of Allergy, Asthma and Immunology. Volume 117, Number 5, Supplement 1. P213. Nov 2016. http://www.annallergy.org/article/S1081-1206(16)31017-1/abstract
Chong-Wei Cui, Joseph Yusin, Inderpal Randhawa. A Non-atopic Child With Recurrent Respiratory Infections Successfully Treated With Mast Cell Therapy. Volume 117, Number 5, Supplement 1. P270. Nov 2016.
Randhawa I, et. Al. Correlation of Negative Tree Nut Skin-Prick Tests and Successful Tree Nut Food Challenges Among Peanut-Allergic Children. Journal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB399. May 2016. http://www.jacionline.org/article/S0091-6749(15)03050-X/abstract
Shin HW, Barletta B, Yoonessi L, Meinardi S, Leu SY, Radom-Aizik S, Randhawa I, Nussbaum E, Blake DR, and Cooper DM. Quantification of Aerosol Hydrofluoroalkane HFA-134a Elimination in the Exhaled Human Breath Following Inhaled Corticosteroids Administration. Clin Transl Sci. 2015 Jul 8. 10.1111/cts.12305 https://www.ncbi.nlm.nih.gov/pubmed/26155923

From Fear and Isolation to Hope and Freedom

Meet just a few of the graduates of our Tolerance Induction Program who now experience true food freedom.

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